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Applikon Biotechnology - More than 30 years of BioProcessing Experience

Company Profile

Applikon Biotechnology is a world leader in developing and supplying advanced bioreactor systems from laboratory scale to production scale. We are the only company that can take a customer from the initial screening stage up to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for our customers' new product development.

Applikon is known for bringing new technologies to the market. These new technologies offer advantages in process efficiency for research and development as well as pilot plant and production scale processes.

As a focused medium sized company we live by our motto "A Step Ahead" to differentiate ourselves from other suppliers. Our focus on developing bioreactor systems only, allows us to produce state-of-the-art equipment. This has resulted in a steady growth to the top position of the worldwide laboratory bioreactor market. The basis for our new product development lies in our strong cooperation with leading international universities and institutes.

As a privately owned company our focus is not on short-term shareholders value but on building a healthy company by supplying the best product offering for our customers now and in the long-term future. This is the basis of many long-term relations with our clients all over the world.

All our efforts are focused on supplying the best solution for our clients in the biotech and pharmaceutical industry. Validation and documentation is a vital part of our development procedures and this is extended throughout our whole company.

Applikon Biotechnology is unique in the mini and micro bioreactor range. No other company can offer a complete solution on this very small scale. We develop systems on a small scale that generate results that can be scaled to production scale. At the moment there are thousands of Applikon bioreactors used in the world from small scale R&D up to full scale cGMP production.

Since we started in 1974 we have shown a healthy growth and profit. R&D is done in house in our headquarters in Delft, The Netherlands. Design and engineering is done in house but real manufacturing is outsourced. Final assembling is done in-house (in our manufacturing sites in Delft and Guangzhou) as well as the final testing and documentation. We have our own sales and service organizations in the USA (Foster City, California and Dover, New Jersey), the UK (Tewkesbury) and China (Guangzhou). We have well trained local distributors for sales and service in over 30 countries.

We are continuously executing strategic plans to grow the top line and strengthen our financial performance. New and ongoing programs are exploring new markets, developing innovative products, improving service to customers, increasing efficiency, and reducing costs.

Our mission: "providing reliable solutions for the bioprocess market that will enable an improved quality of life"



Applikon moves to Delft, our new facility is officially opened by King Willem-Alexander of the Netherlands

Applikon opens manufacturing facility in Science City, Guangzhou, China

2009   Applikon opens a Chinese branch office in Guangzhou, China
2008   The existing management of the company Arthur Oudshoorn, Jaap Oostra and Erik Kakes acquire Applikon Biotechnology BV through a management buyout
2004   Applikon Biotechnology BV is split off as a separate company from Applikon Dependable Instruments BV and Applisens is merged into the new company
2002   Applikon is awarded ISO 9001 certification.
1998   The biotechnology division continues to develop. This leads to a new division, AppliSens. AppliSens specializes itself in the field of sensor technology and special separation systems for perfusion cell cultures.
1992   In collaboration with DHV, Amersfoort and the RIVM, Bilthoven, Applikon was awarded an order from the Chinese government to build these large-scale vaccine plants in China. By securing and successfully completing this project, Applikon becomes a factor with large-scale production plants.
1990   The premises in Schiedam is now increased to 10,000 m2. Another company, Instrumek BV bases its company on the same area and ADI assumes part ownership of Instrumek. Instrumek is specialized in parts for the biotechnology as an analyzer equipment.
1989   The bioreactor program of Contact Flow in Ridderkerk is taken over. Now Applikon gains the technology of the production of child vaccines that was developed with the Dutch Institute for Environmental and Human health issues in Bilthoven.
1988   On request of a few big customers in the USA, Applikon moves its activities to the Bay area in San Francisco; Applikon, Inc. finds its home in Foster City, California. European activities are directed in a positive way with collaboration with Universities and Institutes. New developments are started for extending the product program.
1985   The structure is extended to 2000 sq. meter. The biotechnology activities are put into a new founded company Applikon Dependable Instruments. Into the product range a new group of equipment is introduced. In Situ Sterilizable systems and microprocessor instrumentation for control.
1984   In 1984 Metrohm and the management gains all the shares of Applikon.
1983   The sales activities of the bioreactor system stretches out to other European countries and USA. Especially in the USA, the biotechnology sector starts booming. This leads to an American subsidiary of Applikon in Austin, Texas
1978   In Schiedam a new building is the home base of Applikon. Besides the development of special analyzer equipment for the environmental and the process industry, Applikon starts with the development of small bioreactor systems with control equipment for the biotechnology markets in the Netherlands and Germany.
1974   In 1974 Applikon starts her activities by selling the technical products of Pieterman, the so-called Technical Scientific equipment. The core products are the electrical chemical laboratory analysis instruments of the Swiss Company Metrohm AG. Besides these products, Applikon also represents products of other foreign firms, mainly products based on Biotechnology. Three groups of specialists support these activities, application research, training and project group. This strategy is also anchored in the company name: "Appli" is deducted from the English "to apply"; and the last part "kon" is used in a lot of city names in Switzerland.
1973   Applikon BV was founded in 1973 as a subsidiary of Pieterman BV. Pieterman is a glass industry manufacturer.


ISO Certification: ISO 9001

Applikon is proud to announce that our facilities in Schiedam, the Netherlands has been certified by Det Norske Veritas (DNV) as ISO 9001:2008 compliant. The certification covers business processes including bioreactor development, production, sales, service, customer support, and customised bioreactor system design.

The designation provides additional assurance, from an independent body, to customers and business partners that Applikon has the systems and procedures in place to provide services of consistently high quality. ISO 9001:2000 defines the criteria for a quality system audit and is part of the new ISO 9001:2008 certification requirements.



To further demonstrate the company's commitment to quality and offer customers even greater assurance, Applikon also received the approval to supply fermentors and bioreactor systems according to the new CE guideline; Pressure Equipment Derictive (PED).


PED & CE-Mark

Since November 29th 1999, all pressure equipment with an internal pressure greater than 0,5 bar falls under the Pressure Equipment Directive (PED). The Directive is applicable within the European Economic Area (EU plus Norway, Iceland and Liechtenstein). Pressure equipment can be traded freely within this area once the PED has been complied with. Compliance with the PED therefore ensures no barriers to trade in this area.


At this time, there are no openings at Applikon Biotechnology, Inc. in North America



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